S Spike Protein

Lab Reagents

Human IgG antibody Laboratories manufactures the s spike protein reagents distributed by Genprice. The S Spike Protein reagent is RUO (Research Use Only) to test human serum or cell culture lab samples. To purchase these products, for the MSDS, Data Sheet, protocol, storage conditions/temperature or for the concentration, please contact Spike Protein. Other S products are available in stock. Specificity: S Category: Spike Group: Protein

Protein information

Recombinant SARS Associated Spike Mosaic S(M)

7-07097 500µg Ask for price

Recombinant SARS Associated Spike Mosaic S(M)

7-07098 1000µg Ask for price

Recombinant SARS Associated Spike Mosaic S©

7-07099 100µg Ask for price

Recombinant SARS Associated Spike Mosaic S©

7-07100 500µg Ask for price

Recombinant SARS Associated Spike Mosaic S©

7-07101 1000µg Ask for price

Recombinant (E.Coli) SARS Associated Spike Mosaic S

RP-1422 100 ug
EUR 343.2

Recombinant (E.Coli) SARS Associated Spike Mosaic S

RP-1423 100 ug
EUR 343.2

Recombinant (E.Coli) SARS Associated Spike Mosaic S

RP-1424 100 ug
EUR 343.2

Recombinant Novel Coronavirus Spike Glycoprotein(S), Partial

E80018-1 20 ul
EUR 388.3

Recombinant Novel Coronavirus Spike Glycoprotein(S), Partial

E80018-2 100 ul
EUR 860.2

Recombinant Novel Coronavirus Spike Glycoprotein(S), Partial

E80018-3 1 ml
EUR 4888.4

Recombinant Novel Coronavirus Spike Glycoprotein(S), Partial

E80018
  • EUR 388.30
  • EUR 860.20
  • EUR 4888.40
  • 20 ul
  • 100 ul
  • 1 ml

Goat Anti-MERS-CoV Spike protein S1 (18-524 aa) protein antiserum

MERSS41-S 100 ul
EUR 548.4

Rabbit Anti-Mouse Hepatitis virus (MHV/Coronavirs) Spike Protein S1 antiserum

MHVS13-S 100 ul
EUR 548.4

Recombinant Coronavirus Spike Protein (SARS-CoV S, His tag)

P1520-10 10µg
EUR 308.4

Demeton (O and S)

S-1140 1ML
EUR 71.82

SARS-CoV-2 (COVID-19) Trimeric Spike (S) Recombinant Protein

10-075 0.1 mg
EUR 991.5
Description: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of coronavirus disease 2019 (COVID-19), is an enveloped, single-stranded, positive-sense RNA virus that belongs to the Coronaviridae family 1. The SARS-CoV-2 genome, which shares 79.6% identity with SARS-CoV, encodes four essential structural proteins: the spike (S), envelope (E), membrane (M), and nucleocapsid protein (N) 2. The S protein is a transmembrane, homotrimeric, class I fusion glycoprotein that mediates viral attachment, fusion, and entry into host cells 3. Each ~180 kDa monomer contains two functional subunits, S1 (~700 a.a) and S2 (~600 a.a), that mediate viral attachment and membrane fusion, respectively. S1 contains two major domains, the N-terminal (NTD) and C-terminal domains (CTD). The CTD contains the receptor-binding domain (RBD), which binds to the angiotensin-converting enzyme 2 (ACE2) receptor on host cells 3-5. Although both SARS-CoV and SARS-CoV-2 bind the ACE2 receptor, the RBDs only share ~73% amino acid identity, and the SARS-CoV-2 RBD binds with a higher affinity compared to SARS-CoV 3, 6. The RBD is dynamic and undergoes hinge-like conformational changes, referred to as the “down” or “up” conformations, which hide or expose the receptor-binding motifs, respectively 7. Following receptor binding, S1 destabilizes, and TMPRSS2 cleaves S2, which undergoes a pre- to post-fusion conformation transition, allowing for membrane fusion 8, 9. The S protein has been the main focus of therapeutic and vaccine design as it is highly immunogenic. Both neutralizing antibodies 10,11 and memory T cells 12,13 targeting the S protein are present in the sera of convalescent COVID-19 patients.