S Spike Protein
Lab Reagents
Human IgG antibody Laboratories manufactures the s spike protein reagents distributed by Genprice. The S Spike Protein reagent is RUO (Research Use Only) to test human serum or cell culture lab samples. To purchase these products, for the MSDS, Data Sheet, protocol, storage conditions/temperature or for the concentration, please contact Spike Protein. Other S products are available in stock. Specificity: S Category: Spike Group: Protein
Recombinant SARS Associated Spike Mosaic S(M) |
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7-07097 | CHI Scientific | 500µg | Ask for price |
Recombinant SARS Associated Spike Mosaic S(M) |
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7-07098 | CHI Scientific | 1000µg | Ask for price |
Recombinant SARS Associated Spike Mosaic S© |
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7-07099 | CHI Scientific | 100µg | Ask for price |
Recombinant SARS Associated Spike Mosaic S© |
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7-07100 | CHI Scientific | 500µg | Ask for price |
Recombinant SARS Associated Spike Mosaic S© |
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7-07101 | CHI Scientific | 1000µg | Ask for price |
Recombinant (E.Coli) SARS Associated Spike Mosaic S |
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RP-1422 | Alpha Diagnostics | 100 ug | EUR 343.2 |
Recombinant (E.Coli) SARS Associated Spike Mosaic S |
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RP-1423 | Alpha Diagnostics | 100 ug | EUR 343.2 |
Recombinant (E.Coli) SARS Associated Spike Mosaic S |
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RP-1424 | Alpha Diagnostics | 100 ug | EUR 343.2 |
Recombinant Novel Coronavirus Spike Glycoprotein(S), Partial |
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E80018-1 | EpiGentek | 20 ul | EUR 388.3 |
Recombinant Novel Coronavirus Spike Glycoprotein(S), Partial |
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E80018-2 | EpiGentek | 100 ul | EUR 860.2 |
Recombinant Novel Coronavirus Spike Glycoprotein(S), Partial |
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E80018-3 | EpiGentek | 1 ml | EUR 4888.4 |
Recombinant Novel Coronavirus Spike Glycoprotein(S), Partial |
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E80018 | EpiGentek |
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Goat Anti-MERS-CoV Spike protein S1 (18-524 aa) protein antiserum |
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MERSS41-S | Alpha Diagnostics | 100 ul | EUR 548.4 |
Rabbit Anti-Mouse Hepatitis virus (MHV/Coronavirs) Spike Protein S1 antiserum |
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MHVS13-S | Alpha Diagnostics | 100 ul | EUR 548.4 |
Recombinant Coronavirus Spike Protein (SARS-CoV S, His tag) |
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P1520-10 | Biovision | 10µg | EUR 308.4 |
Demeton (O and S) |
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S-1140 | Scientific Laboratory Supplies | 1ML | EUR 71.82 |
SARS-CoV-2 (COVID-19) Trimeric Spike (S) Recombinant Protein |
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10-075 | ProSci | 0.1 mg | EUR 991.5 |
Description: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of coronavirus disease 2019 (COVID-19), is an enveloped, single-stranded, positive-sense RNA virus that belongs to the Coronaviridae family 1. The SARS-CoV-2 genome, which shares 79.6% identity with SARS-CoV, encodes four essential structural proteins: the spike (S), envelope (E), membrane (M), and nucleocapsid protein (N) 2. The S protein is a transmembrane, homotrimeric, class I fusion glycoprotein that mediates viral attachment, fusion, and entry into host cells 3. Each ~180 kDa monomer contains two functional subunits, S1 (~700 a.a) and S2 (~600 a.a), that mediate viral attachment and membrane fusion, respectively. S1 contains two major domains, the N-terminal (NTD) and C-terminal domains (CTD). The CTD contains the receptor-binding domain (RBD), which binds to the angiotensin-converting enzyme 2 (ACE2) receptor on host cells 3-5. Although both SARS-CoV and SARS-CoV-2 bind the ACE2 receptor, the RBDs only share ~73% amino acid identity, and the SARS-CoV-2 RBD binds with a higher affinity compared to SARS-CoV 3, 6. The RBD is dynamic and undergoes hinge-like conformational changes, referred to as the “down” or “up” conformations, which hide or expose the receptor-binding motifs, respectively 7. Following receptor binding, S1 destabilizes, and TMPRSS2 cleaves S2, which undergoes a pre- to post-fusion conformation transition, allowing for membrane fusion 8, 9. The S protein has been the main focus of therapeutic and vaccine design as it is highly immunogenic. Both neutralizing antibodies 10,11 and memory T cells 12,13 targeting the S protein are present in the sera of convalescent COVID-19 patients. |